1. Sorrentino F., Gonzalez del Rio R., Zheng, X., Matilla, J.P., Torres Gomez, P., Hoyos, M.M., Perez Herran. M, E., Mendoza Losana, A., Av-Gay, Y. (2015). Development of an intracellular screen for new compounds able to kill Mycobacterium tuberculosis in human macrophages. Antimicrob Agents Chemother. 60(1):640-5.
  2. Zheng, X., Av-Gay, Y. (2016). New era of TB drug discovery and its impact on disease management. Review. Curr Treat Options Infect Dis. doi:10.1007/s40506-016-0098-0
  3. Zheng, X., Av-Gay, Y. (2017). System for efficacy and cytotoxicity screening of inhibitors targeting intracellular Mycobacterium tuberculosis. J. Vis. Exp. e55273, doi:10.3791/55273.
  4. Richter, A., Angelika Strauch, Joseph Chao, Mary Ko, Av-Gay Y. (2018). Screening of Preselected Libraries Targeting Mycobacterium abscessus for Drug Discovery. Antimicrobial Agents and Chemotherapy. 62(9). e00828-18. doi:10.1128/AAC.00282-18
  5. Richter A, Shapira T, Av-Gay Y. (2019). THP-1 and Dictyostelium infection models for screening and characterization of anti-Mycobacterium abscessus hit compounds. Antimicrob Agents Chemother https:// DOI: 10.1128/AAC.01601-19
  6. Shapira T, Rankine-Wilson L, Chao J, Pichler V, Rens C, Pfeifer T, Av-Gay Y. (2020). High-content screening of eukaryotic kinase inhibitors identify CHK2 inhibitor activity against Mycobacterium tuberculosis. Frontiers in microbiology. 11:2238. doi: 10.3389/fmicb.2020.553962
  7. Moure AL, Narula G, Sorrentino F, Bojang A, Tsui CKM, Sao Emani C, Porras-De Francisco E, Díaz B, Rebollo-López MJ, Torres-Gómez PA, López-Román EM, Camino I, Casado Castro P, Guijarro López L, Ortega F, Ballell L, Barros-Aguirre D, Remuiñán Blanco M, Av-Gay Y. (2020). MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against Mycobacterium tuberculosis. J Med Chem. 2020;63(9):4732‐4748. doi:10.1021/acs.jmedchem.0c00003
  8. Sahile HA, Rens C, Shapira T, Andersen RJ, Av-Gay Y. (2020). DMN-Tre Labeling for Detection and High-Content Screening of Compounds against Intracellular Mycobacteria ACS Omega, 5: 7, 3661-3669.
  9. Richter, A., Narula, G., Rudolph, I., Seidel, R., Wagner, C., Av-Gay, Y., Imming, P. (2021). Efficient synthesis of benzothiazinone analogues with activity against intracellular Mycobacterium tuberculosis. ChemMedChem. e202100733
  10. Rens, C., Shapira, T., Peña-Diaz, S., Chao, D, J., Pfeifer, T., and Av-Gay Y. (2021). Apoptosis Assessment in High-Content and High-Throughput Screening Assays. Biotechniques. 70(6): 309-318
  11. Sahile, HA, Williams D.E., de Voogd, N.J., Ko, M., Andersen, R.J., Av-Gay Y. (2022). Screening of diverse marine invertebrate extracts identified Lissoclinotoxin F, Discodermin B, and other anti-Mycobacterium tuberculosis active compounds. J Antibiotics. DOI: 10.1038/s41429-022-00507-9.
  12. Persaud R. Li S, Chao, J., Forestieri, R., Donohue, E., Zheng, X., Chao, J.T., Yashiroda Y., Patrick, BO., Loewen,C., Gingras, AC., Boone, C., Av-Gay,Y., Roberge, M., and Andersen. RJ. (2022). Clionamine Analogs Stimulate Autophagy and Inhibit Mycobacterium tuberculosis Survival in Human Macrophages: Synthesis and Molecular Target Identification. Cell Chemical Biology. 29:1-113

Clinical development:

  1. Tal, A., Greenberg, D., Av-Gay, Y., Golan-Tripto, I., Feinstein, Y., Ben-Shimol, S., Dagan, R., Goldbart, A.D., (2017). Nitric oxide inhalations in bronchiolitis: A pilot, randomized, double-blinded, controlled trial. Pediatr Pulmonol. doi:10.1002/ppul.23905.
  2. Margel, D., Mizrahi, M., Regev-Shoshani, G., Ko, M., Moshe, M., Ozalvo, R., Shavit-Greivink, L., Baniel, J., Kedar, D., Yossepowitch. O., Lifshitz, D., Nadu, A., Greenberg, D., and Av-Gay, Y., (2017). Nitric Oxide Charged Catheters as a Potential Strategy for Prevention of Hospital Acquired Infections. Plos One. Apr 14;12(4):e0174443. doi: 10.1371/journal.pone.0174443.